CURRICULUM VITAE SFEIR

Stop pulling my strings – what telomeres taught us about the DNA damage response. Opens in a new tab. Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. Is this your profile?

To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. Our lab is mainly interested in understanding the basic mechanism that leads to telomere length resetting. Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Associate Professor, Department of Cell Biology. PhD from Southwestern University. In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length.

Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates.

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The former stems from the inherent inability of the replication machinery to fully duplicate linear templates. Stop pulling my strings – what telomeres taught us about the DNA damage response.

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Agnel Sfeir is mainly interested in understanding the basic mechanism that leads to telomere length resetting.

In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length. PhD from Southwestern University.

Rana Salam Curriculum Vitae

Areas of Research Interest and Expertise: Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Associate Professor, Department of Cell Biology.

Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development.

A second area of their interest is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

Ramin Haerizadeh Curriculum Vitae – Selections Arts

The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. The linearity of chromosomes creates two major problems for eukaryotic cells: Our lab is mainly interested in understanding the basic mechanism that leads to telomere length resetting. Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity.

curriculum vitae sfeir

Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Is this your profile?

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curriculum vitae sfeir

Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination. Journal of Cell Science.

curriculum vitae sfeir

The linearity of chromosomes creates two major problems for eukaryotic cells: To surmount both problems, cells use telomeres, the specific curricuulm complexes that are essential to ensure genomic stability and promote cellular survival. A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

Stressed telomeres without POT1 enhance tumorigenesis [Editorial]. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

Hesam Rahmanian Curriculum Vitae

Opens vitse a new tab. Telomeres at a glance. See All Publications Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development.

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